Tiers lieu: IN CITU - Citizen Innovations in Digital Health
Led by Lille University Hospital
The priorities of the Tiers lieu are defined by the region’s healthcare needs, in collaboration with patients and healthcare professionals. The Tiers lieu offers experimental sites distributed throughout the Hauts-de-France region

+200
available test sites in the Hauts-de-France region
15
supervised pilot projects
+30
events where IN CITU was present
Services Offered by the Tiers lieu
The IN CITU Tiers lieu offers comprehensive strategic support, from validating the need and relevance of the solution through to its implementation. The Tiers lieu provides access to suitable testing sites (hospitals, university hospitals, clinics, outpatient care centers, medical-social facilities, etc.) and assists with the drafting of protocols, including regulatory procedures and the conduct of real-world trials. The team coordinates projects and evaluations to ensure targeted studies with robust methodologies and relevant indicators.
IN CITU conducts feasibility studies (organizational, clinical, digital, usage, etc.) to complement technology validation, as well as impact studies (clinical, organizational, health economics, quality of life, usage, etc.), incorporating the development of quantifiable indicators and the preparation of regulatory requirements, in order to optimize market access and enhance the chances of approval by bodies such as the HAS.
The Tiers lieu Experimentation Projects
Project 1: MARCHESE
Supplier: CERN (European Organization for Nuclear Research)
Solution: MARCHESE is an innovative, reliable, and low-cost contactless physiological monitoring device. It continuously records vital signs.
Need: Some patients require close monitoring of vital signs but have little or no tolerance for conventional monitors, as these require the use of invasive equipment.
IN CITU Contribution: Pilot feasibility study in a geriatric ward to assess the reliability of measurements, the organizational feasibility of implementing this device, and its acceptability.
Project 2: PIXACARE
Supplier: PIXACARE
Solution: Secure remote monitoring platform for chronic wounds designed to optimize multidisciplinary coordination.
Need: The management of chronic wounds, which is complex and marked by gaps in care between the hospital and the home, leads independent nurses to send photos to specialists, often via unsecured channels, due to a lack of responsive solutions for complications.
IN CITU Contribution: A randomized study showing that remote monitoring reduces the need for in-person consultations with a wound care specialist at a hospital or wound and healing center compared to conventional care for patients with chronic wounds.
Project 3: ANS GUARDIAN
Supplier: Lille University Hospital
Solution: Device for assessing the comfort of conscious, non-communicative patients.
Need: The need for reliable and appropriate tools to assess the clinical comfort of non-communicative end-of-life patients is a major challenge in improving the quality of palliative care.
IN CITU’s contribution: Impact assessment study on professional practices and families.
Project 4: ROMAIN
Supplier: iAVC
Solution: A patient geolocation system for emergency situations that informs all professionals involved in the process during inter-hospital transfers.
Need: Establishing an optimized organizational structure for human resources during inter-hospital transfers of stroke patients is a major challenge aimed at streamlining care pathways, reducing response times, and preserving the quality of life for healthcare professionals.
IN CITU’s Contribution: An evaluation study of the system’s transferability, utility, and acceptability, as well as its impact on response times, to prepare a project proposal and consolidate the evidence for broader deployment.
Project 5: LORIO
Supplier: Happlyz Medical
Solution: An innovative digital medical device combining an electronic flute with an interactive video game platform, offering a motivating and engaging approach to respiratory exercises
Need: Respiratory rehabilitation, which is effective after a course of at least 8 weeks, sees its benefits diminish after one year, raising the question of how to maintain progress—an area where remote monitoring could play a key role.
IN CITU’s Contribution: A randomized study showing that home-based remote monitoring incorporating the LORIO system in addition to standard care reduces the number of COPD-induced exacerbations in the year following discharge from the rehabilitation center, compared to standard care, in patients with COPD.
Happlyz